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    叶升

    医疗特长:

    从事肿瘤内科领域三十余年,是资深临床肿瘤专家。擅长罕见肿瘤、肺癌、胃癌、结直肠癌、肝癌、膀胱癌、肾癌等恶性肿瘤的诊断及综合治疗,尤其是恶性肿瘤的免疫治疗、分子靶向治疗及化疗。


    主要教育和工作经历: 

    1986年中山医科大学毕业,先后获硕士、博士学位。从事临床肿瘤诊疗工作三十余年,曾任中山大学附属第一医院肿瘤科主任多年。
    社会兼职:现任中国肿瘤临床学会(CSCO)理事、CSCO罕见肿瘤专委会常委、中华医学会肿瘤分会肿瘤内科专委会委员、中国南方肿瘤临床研究协会(CSWOG)常委;广东省抗癌协会化疗专委会副主委;广东省健康管理学会副秘书长及肿瘤防治专委会副主委;广州抗癌协会胃癌专委会主委等。


    主要论著(SCI,第一作者/通信作者):

    1Ying He*, Zhousan Zheng*, Yi Xu*,Huiwen Weng, Ying Gao, Kai Qin, Jian Rong, Cui Chen, Miao Yun, Jiaxing Zhang,Sheng Ye(叶升,通讯作者).Over-expression of IMPDH2 isassociated with tumor progression and poor prognosis in hepatocellularcarcinoma.Am J Cancer Res 2018;8(8):1604-1614.(IF=4.737)

    2Yi Xu#, Zhousan Zheng#, Ying Gao#,Shiyu Duan, Cui Chen, Jian Rong, Kebing Wang,MiaoYun, Huiwen Weng, ShengYe*(叶升,共同通讯作者) & Jiaxing Zhang*. High expressionof IMPDH2 is associated with aggressive features and poor prognosis of primarynasopharyngeal carcinoma. Scientific Reports. 2017 Apr 7;7(1):745.(IF=4.122)

    3Ying Gao#, Mengping Zhang #, Zhousan Zheng#, Ying He #, YujiaZhu, Quanyong Cheng, Jian Rong, Huiwen Weng, Cui Chen, Yi Xu, Miao Yun, JiaxingZhang* and Sheng Ye*(叶升,通讯作者). Over-expression of protein tyrosinephosphatase 4A2 correlates with tumor progression and poor prognosis innasopharyngeal carcinoma. Oncotarget. 2017 Aug24;8(44):77527-77539.(IF=5.168

    4Zhang JX,  Chen ZH, Xu Y,  Chen JW,  Weng HW, Yun M,  Zheng ZS,  Chen C, Wu BL, Li EM, Fu JH,Ye S(叶升,通讯作者), and Xie D. Downregulation of MicroRNA-644a Promotes Esophageal Squamous Cell Carcinoma Aggressivenessand Stem-cell-like Phenotype via Dysregulation of PITX2. Clinical CancerResearch(IF=8.738).2016 Jul 12. pii:clincanres.0414.2016. doi:10.1158/1078-0432.CCR-16-0414.PMID: 27407092.

    5XuY, Rong J, Duan SY, Chen C, Li Y, Peng BG, Yi B,Zheng ZS, Gao Y, Wang KB, YunM, Weng HW, Zhang JX, Ye S(叶升,通讯作者).High expression of GNA13 is associated with poor prognosis inhepatocellular carcinoma.Scientific Reports(IF=5.228).

    6Zhang JX, Yun M, Xu Y, Chen JW, WengHW, Zheng ZS, Chen C, Xie D, YeS(叶升,通讯作者).GNA13 as a prognostic factor and mediator of gastriccancerprogression.Oncotarget(IF=6.359).2015 Dec 28. doi: 10.18632/oncotarget.6780. [Epub ahead ofprint]PubMed PMID:26735177.

    7Chen C, Sun P, Rong J, Weng HW, DaiQS, Ye S叶升,通讯作者. Short Course Radiation intheTreatment of Localized Rectal Cancer: A Systematic Review andMeta-Analysis. Sci Rep(IF=5.578). 2015 Jun 9;5:10953. doi:10.1038/srep10953. PubMedPMID: 26055266; PubMed Central PMCID: PMC4460726.

    8Yun M, Rong J, Lin ZR, He YL, ZhangJX, Peng ZW, Tang LQ, Zeng MS,Zhong Q, Ye S(叶升,通讯作者). High expression of transformingacidic coiled coil-containingprotein 3 strongly correlates with aggressivecharacteristics and poorprognosis of gastric cancer. OncolRep(IF=2.301). 2015 Sep;34(3):1397-405.doi:10.3892/or.2015.4093. Epub 2015 Jun 30. PubMed PMID: 26133271.

    9Yun M, Bai HY, Zhang JX, Rong J, WengHW, Zheng ZS, Xu Y, Tong ZT,Huang XX, Liao YJ, Mai SJ, Ye S(叶升,通讯作者), Xie D. ULK1: a promising biomarkerinpredicting poor prognosis and therapeutic response in humannasopharygealcarcinoma. PLoS One(IF=3.234). 2015 Feb 25; 10(2): e0117375.doi:10.1371/journal.pone.0117375. eCollection 2015.PubMed PMID: 25714809;PubMed CentralPMCID: PMC4340914.

    10Zheng Z, Shao N, Weng H, Li W, ZhangJ, Zhang L, Yang L, Ye S(叶升,通讯作者).Correlation between epidermal growth factor receptor andtumor stem cellmarkers CD44/CD24 and their relationship with prognosis inbreast invasiveDuctalcarcinoma.

    MedOncol(IF=2.634).2015Jan;32(1):275.doi:10.1007/s12032-014-0275-2.Epub 2014 Nov 28.PubMed PMID: 25429827;PubMed Central PMCID: PMC4246130.

    11ChenC, Sun P, Dai QS, Weng HW, Li HP, Ye S(叶升,通讯作者). The Glasgow PrognosticScore predicts poor survival incisplatin-based treated patients withmetastatic nasopharyngeal carcinoma. PLoSOne(IF=3.534). 2014 Nov 13;9(11):e112581.doi: 10.1371/journal.pone.0112581.eCollection 2014. PubMed PMID: 25393117;PubMed Central PMCID: PMC4230992.

    12ZouJY, Huang SH, Li Y, Chen HG, Rong J, Ye S(叶升,通讯作者). Airway epithelialcell-derivedinsulin-like growth factor-1 triggers skewed CD8(+) T cellpolarization. CellBiol Int(IF=1.635). 2014 Oct;38(10):1148-54. doi: 10.1002/cbin.10313.Epub2014 Jul 16. PubMed PMID: 24844927.

    13OuyangM, Li Y, Ye S(叶升,共同第一), Ma J, Lu L,Lv W, Chang G, Li X, LiQ, Wang S,Wang W. MicroRNA profiling implies new markers of chemoresistanceoftriple-negative breastcancer.PLoSOne(IF=3.534).2014May2;9(5):e96228.doi:10.1371/journal.pone.0096228. eCollection 2014. PubMed PMID:24788655;PubMed Central PMCID: PMC4008525.

    14HuangSH, Li Y, Chen HG, Rong J, Ye S(叶升,通讯作者). Activation of proteinase-activatedreceptor 2 preventsapoptosis of lung cancer cells. Cancer Invest(IF=2.238).2013Nov;31(9):578-81. doi: 10.3109/07357907.2013.845674. Epub 2013 Oct18.PubMed PMID: 24138209.

    15Gao L, Mai A, Li X, Lai Y, ZhengJ,Yang Q,Wu J, Nan A, Ye S(叶升,通讯作者), Jiang Y.LncRNA-DQ786227-mediated cell malignanttransformation induced bybenzo(a)pyrene. Toxicol Lett(IF=3.145). 2013Nov 25;223(2):205-10. doi:10.1016/j.toxlet.2013.09.015. Epub 2013 Sep29.PMID:24084393.

    16Rong J, Wang S, Ding Q, Yun M, ZhengZ, Ye S(叶升,通讯作者). Comparison of 18 FDGPET-CT and bonescintigraphy for detection of bone metastases in breastcancer patients.Ameta-analysis. Surg Oncol(IF=2.136).2013 Jun;22(2):86-91. doi:10.1016/j.suronc.2013.01.002. Epub2013 Feb 8. Review. PubMed PMID:23726506.

    17Rong J, Ye S(叶升,共同第一), Liang MY, Chen GX, Liu H, Zhang JX,Wu ZK. Receptor foradvanced glycation end products involved in lung ischemiareperfusioninjury in cardiopulmonary bypass attenuated by controlledoxygenreperfusion in a canine model. ASAIO J(IF=1.491).2013 May-Jun;59(3):302-8. doi:10.1097/MAT.0b013e318290504e. PubMed PMID:23644619.

    18Huang SH, Li Y, Zhang J, Rong J, Ye S(叶升,通讯作者). Epidermal Growth Factor

    Receptor-Containing Exosomes Induce Tumor-Specific RegulatoryT Cells.Cancer InvestIF=2.238. 2013 Jun;31(5):330-5. doi: 10.3109/07357907.2013.789905.Epub2013 Apr 24.PMID:23614656.


    专著:

    1、《恶性淋巴瘤诊断治疗学》--编委

    出版社:人民卫生出版社

    2、《胰腺癌临床实践--争论与共识》--编委

    出版社:广东科技出版社

    3、《实用胃肠恶性肿瘤诊疗学》--编委

    出版社: 广东科技出版社

    4、《全国县级医院肿瘤学手册》--主编秘书单位

    出版社:人民卫生出版社

    5、《肿瘤分子靶向诊疗学》--副主编

    出版社:人民卫生出版社


    其他主要工作成绩(比如获奖情况):

    在临床医疗工作中,按照最新进展开展规范化诊疗,在精准医学时代,力求做到对每位病患提供高水平治疗。 善于利用了高水平大型综合医院的优势,经常为疑难重症患者组织多学科MDT协作会诊,为疑难重症患者制定个体化诊治方案, 疑难病人的诊治达到国内领先水平。积极

    参加医院其他科室肿瘤患者的MDT会诊,为大量疑难病例提供最优诊治措施。

    作为中山大学附属第一医院的科主任带领肿瘤科成功申报“国家临床重点专科建设项目”以及广东省重点专科。

    定期组织及主办各类学术会议,在学术上影响力稳步提升,反响热烈。定期举办关于肿瘤筛查与防治、姑息与康复等相关知识的宣教讲座,深受病人和家属们的一致好评,全年病人满意度达100%。积极参与干部保健工作和国家医疗队义诊及授课工作并获得极高的评价,在2016年被评为“优秀保健工作者”。在2019年被评为“胡润平安中国好医生”。

    积极开展最新临床试验研究,已参与完成多项临床研究,目前正开展免疫治疗联合化疗在晚期肺癌的III期临床研究。


    科研基金:

    1、国家自然科学基金(2018)候选癌基因GNA13调控外泌体促进食管鳞癌转移的作用及分子机制研究(主持)

    2、广东省科技计划项目(2014年)“非小细胞肺癌患者血清中AQP1抗体的检测及其与预后的关系” (主持)

    3、广东省科技计划项目(2013年) MiRNA-124a对胃癌细胞EMT与复发转移的初步研究”(主持)

    4、广东省自然科学基金(2010年)“非小细胞肺癌血清新型生物标记的筛选与鉴定”(主持)


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