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    纪卫东

    纪卫东
    • 科  室:
    • 职  称:研究员
    • 导师资格:博士生导师
    • 最高学历:博士
    出诊时间
    周一 周二 周三 周四 周五 周六 周日
    上午
    下午
    晚上
    (注:出诊信息仅供参考,有可能随时更新,以门诊公布为准。)

    医疗/科研特长

    长期从事化学致癌表观遗传机制和肿瘤血管发生的信号传导通路研究,发表SCI论文40余篇,包括发表在J .Exp Med.Nat Med.Nat Commun.JCI J Allergy Clin Immunol.Cancer Res.OncogeneCarcinogenesis等国际著名专业期刊杂志,主持国家、省市各类科研项目10余项,获科研成果奖励9项。

     

    研究方向:

    化学致癌和膀胱癌的表观遗传机制

     

    主要教育和工作经历:

    19926月毕业于安徽医科大学,获预防医学学士学位;20016月毕业于广州医科大学,获卫生毒理学硕士学位;20086月毕业于中山大学,获卫生毒理学博士学位;20017月至20145月在广州医科大学从事教学科研工作, 200810月至20119月期间,在耶鲁大学医学院从事病理学博士后研究; 20146月作为中山大学“百人计划”人才引进至中山大学附属第一医院转化医学研究中心工作。


    社会兼职:

    国家自然科学基金面上项目和广东省自然科学基金项目通讯评审专家,广东省、广州市科技成果评审专家;中国毒理学会生化与分子毒理专业委员会委员、中国转化医学联盟理事、广东省转化医学会理事、广东省环境诱变剂学会理事、广东省医学会医学科研实验室建设与管理分会委员、广东省医院协会科研实验室建设与管理分会常委。

     

    论著:

    1.      Wei Y#, Zhang J#, Wu X, Sun W, Wei F, Liu W, Lu T, Ji W*, Li H*, Wen W*.  Activated pyrin domain containing 3 (NLRP3) inflammasome in neutrophilic chronic rhinosinusitis with nasal polyps (CRSwNP). J Allergy Clin Immunol. 2020;S0091-6749(20)30072-5.

    2.      Jin H#, Ying X#, Que B, Wang X, Chao Y, Zhang H, Yuan Z, Qi D, Lin S, Min W, Yang M*, Ji W*. N(6)-methyladenosine modification of ITGA6 mRNA promotes the development and progression of bladder cancer. EBioMedicine. 2019, 47:195-207. PMID: 31409574.

    3.      Yang F#, Jin H#, Que B#, Chao Y#, Zhang H, Ying X, Zhou Z, Yuan Z, Su J, Wu B, Zhang W, Qi D, Chen D, Min W*, Lin S*, Ji W*. Dynamic m6A mRNA methylation reveals the role of METTL3-m6A-CDCP1 signaling axis in chemical carcinogenesis. Oncogene. 2019;38(24):4755-4772.

    4.      Chao Y, Shang J*, Ji W*. ALKBH5-m6A-FOXM1 signaling axis promotes proliferation and invasion of lung adenocarcinoma cells under intermittent hypoxia. Biochem Biophys Res Commun. 2020; 521(2):499-506.

    5.      Yuan G, Chen T, Zhang H, Cao Q, Qiu Y, Que B, Peng S, Chen M*, Ji W*. Comprehensive analysis of differential circular RNA expression in a mouse model of colitis-induced colon carcinoma. Mol Carcinog. 2018 Sep 4. doi:10.1002/mc.22900. 

    6.      Zhang H, Qi D, Li J, Peng T, Yang L, Yuan J, Zhang Y, Hu Y, Su J, Que B, Li M, Zhou G, Chen Y, Zhang W*, Ji W*. A novel regulatory circuit of miR?152 and DNMT1 in human bladder cancer. Oncol Rep. 2018 Sep;40(3):1803-1812. 

    7.      He J, Huang S, Lin Z, Zhang J, Su J, Ji W*, Liu X*. Disabled homolog 2 interactive protein functions as a tumor suppressor in osteosarcoma cells. Oncol Lett. 2018 Jul;16(1):703-712. 

    8.      Mingzhu Yin, Huanjiao Jenny Zhou, Jiqin Zhang, Caixia Lin, Hongmei Li, Xia Li, Yonghao Li, Haifeng Zhang, David G. Breckenridge, Ji W, and Wang Min*,ASK1-dependent endothelial cell activation is critical in ovarian cancer growth and metastasis, 2017.

    9.      Yin M, Li X, Tan S, Zhou HJ, Ji W, Bellone S, Xu X, Zhang H, Santin AD, Lou G, Min W*. Tumor-associated macrophages drive spheroid formation during early transcoelomic metastasis of ovarian cancer. J Clin Invest. 2016 Nov 1;126(11):4157-4173.

    10.   Qi D, Li J, Que B, Su J, Li M, Zhang C, Yang M, Zhou G, Ji W*. Long non-coding RNA DBCCR1-003 regulate the expression of DBCCR1 via DNMT1 in bladder cancer. Cancer Cell Int. 2016 Oct 18;16:81.

    11.  Zhou HJ, Qin L, Zhang H, Tang W, Ji W, He Y, Liang X, Wang Z, Yuan Q, Vortmeyer A, Toomre D, Fuh G, Yan M, Kluger MS, Wu D*, Min W*. Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation. Nat Med. 2016 Sep;22(9):1033-42.

    12.  Gao Y, Yin Y, Xing X, Zhao Z, Lu Y, Sun Y, Zhuang Z, Wang M, Ji W*, He Y*. Arsenic-induced anti-angiogenesis via miR-425-5p-regulated CCM3. Toxicol Lett. 2016 Jul 8;254:22-31.

    13.  Chen Y, Zhang H, Zhou HJ, Ji W, Min W*. Mitochondrial Redox Signaling and TumorProgression. Cancers (Basel). 2016 Mar 25;8(4). pii: E40.

    14.  Shao L, Zhou HJ, Zhang H, Qin L, Hwa J, Yun Z, Ji W, Min W*. SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression. Nat Commun. 2015 Nov 24;6:8917.

    15.  Ji W, Li Y, He Y, Yin M, Zhou HJ, Boggon TJ, Zhang H, Min W*. AIP1 Expression in Tumor Niche Suppresses Tumor Progression and Metastasis.[J]. Cancer Research, 2015, 75(17):3492-504.

    16.  Ji W, Yang M, Praggastis A, Li Y, Zhou HJ, He Y, Ghazvinian R, Cincotta DJ, Rice KP, Min W. Carbamoylating Activity Associated with the Activation of the Antitumor Agent Laromustine Inhibits Angiogenesis by Inducing ASK1-Dependent Endothelial Cell Death. PLoS One. 2014 Jul 28;9(7):e103224.

    17.  Qi D, Hu Y, Zhang Y, Peng T, Ji W*.Effect of Ku70 expression on radiosensitivity in renal carcinoma 786-O cells. Cancer Cell Int. 2014 May 26;14:44.

    18.  Ji W*Yang L , Yuan J , Yang L , Qi D , Zhang M , Lu J , Zhuang Z , Zeng G* .MiRNA-152 Targets DNA Methyltransferase 1 in NiS-transformed Cells via a Feedback Mechanism . Carcinogenesis . 2013.34(2):446-53.

    19.  Ji W #, Li Y  # , Wan T , Wang J , Zhang H , Chen H* , Min W* . Both Internalization and AIP1 Association Are Required for Tumor Necrosis Factor Receptor 2-Mediated JNK Signaling . Arterioscler Thromb Vasc Biol . 2012.32(9):2271-9.

    20.  Yang L , Li Y , Ling X , Liu L , Liu B , Xu K , Bin X , Ji W*, Lu J * . A Common Genetic Variant (97906C>A) of DAB2IP/AIP1 Is Associated with an Increased Risk and Early Onset of Lung Cancer in Chinese Males . PLoS One . 2011.6(10):e26944.

    21.  Yu L # , Ji W #, Zhang H, Renda MJ , He Y , Lin S ,  Cheng EC , Chen H , Krause DS , Min W* . SENP1-mediated GATA1 desumoylation is critical for definitive erythropoiesis . J Exp Med . 2010.207(6):1183-95.

    22.  Ji W Yang L , Yu L , Yuan J , Hu D , Zhang W , Yang J , Pang Y , Li W , Lu J , Fu J , Chen J , Lin Z , Chen W* , Zhuang Z* . Epigenetic silencing of O6-methylguanine DNA methyltransferase in nickel-transformed cells. Carcinogenesis. 2008.29(6):1267-75.

    23.  Yang L, Yang X, Ji W, Deng J, Qiu F, Yang R, Fang W, Zhang L, Huang D, Xie C, Zhang H, Zhong N, Ran P, Zhou Y, Lu J*. Effects of a Functional Variant c.353T>C in Snai1 on Risk of Two Contextual Diseases. Chronic Obstructive Pulmonary Disease and Lung Cancer. Am J Respir Crit Care Med. 2014.189(2):139-48.

    24.  Liu B # , Yang L # , Huang B , Cheng M , Wang H , Li Y , Huang D , Zheng J , Li Q , Zhang X , Ji W , Zhou Y , Lu J *. A Functional Copy-Number Variation in MAPKAPK2 Predicts Risk and Prognosis of Lung Cancer . Am J Hum Genet . 2012.91(2):384-90.

     

    专著:

    其他主要工作成绩(比如获奖情况):

    主持5项国家自然科学基金面上项目和省、市等各类项目共计10余项;申请发明专利5项。

    获奖情况:

    1.《典型环境毒物的表观遗传效应研究》,广东省科技进步奖二等奖(第二完成人)2014

    2.《结晶型NiS诱发的转化细胞中MGMT基因表观遗传调控》,第二届南粤科技创新优秀学术论文一等奖(第一完成人)2011

    3.《肺癌化学病因及其干预的实验研究》,广东省科技进步二等奖、广州市科技进步一等奖、中华预防医学会科技进步三等奖(第三完成人)20082007

    4.《结晶型NiS诱发人支气管上皮细胞系恶性转化》,中国毒理学会中青年优秀论文奖,(第一完成人) 2001

    5.《镍化合物致癌分子机制系列研究》,广州市科技进步二等奖(第二完成人),2006

    6.Epigenetic silencing of O6-methylguanine DNA methyltransferase in nickel-transformed cells》,    The 4th International Congress of Asian Society of Toxicology Best Poster Award, (第一完成人)2006

    7.《代表性环境化学污染物致DNA损伤修复机制及相关基因多态性研究》,中华医学会科技进步三等奖(第四完成人),2011